why do you have to take nifedipine on an empty stomach viramune

Available for Android and iOS devices. If you stop taking the drug suddenly or dont take it at all: If you take this drug to treat high blood pressure, your blood pressure may increase. This activity outlines the indications, mechanism of action, methods of . Limit alcoholic beverages. Swallow it whole. Nifedipine passes into breast milk. All rights reserved. A new program developed by a research team focuses on diet, exercise, and sleep as the keys to lowering your blood pressure without using drugs. Before taking nifedipine, tell your doctor if you have kidney or liver disease, a blockage in your digestive tract (stomach or intestines), a history of stomach surgery, coronary artery disease, underactive thyroid, diabetes, or congestive heart failure. Uses. Take your next dose at the regular time. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. Using digoxin with nifedipine can increase or decrease the amount of digoxin in your body. If you're not sure, check with your doctor or pharmacist. Some supplements and medications can also interfere with the way . Eat a diet rich in fruits, vegetables, nuts, seeds, and legumes. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Timing of . Do not double doses. etravirine (Intelence) Take with or after food (within two hours after a main meal or within half an hour after a snack). Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. This is due to the refluxed acid irritating the windpipe (trachea). Always discuss possible side effects with a healthcare professional who knows your medical history. Your doctor will tell you which of these are most important for you. While it is generally believed that nighttime blood pressure medications are helpful for those with non-dipping blood pressure, this new study seems to indicate that it might be helpful in more effectively lowering blood pressure for a broader range of people. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. This site complies with the HONcode standard for trustworthy health information: verify here. The following information includes only the average doses of this medicine. include protected health information. This site complies with the HONcode standard for trustworthy health information: verify here. Talk to your doctor before using this form of nifedipine if you have galactose intolerance, or severe problems with lactose (milk sugar). You will need to buy a home blood pressure monitor to do this. Runny nose. Exercise regularly (over 150 minutes per week). Some medicines need to be taken "before food" or "on an empty stomach". Nifedipine should not be used to rapidly drop blood pressure as this may be fatal and it should not be taken with grapefruit juice or grapefruit products. Follow your doctor's orders or the directions on the label. Some products have ingredients that could raise your heart rate or blood pressure. Foods containing soy and cottonseed meal can make Synthroid less effective. In this case leave out the missed dose and take your next dose at the usual time, like your heart is not beating normally (irregular heartbeats), you take more than your prescribed dose of nifedipine. Your doctor may advise you to take sublingual nitroglycerin during the initial administration of nifedipine. These are all extended-release tablets. Talk with your doctor about other drug options that may work for you. This information is not a substitute for medical advice. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Grapefruit juice can increase the amount of certain medications in your bloodstream. Non-dipping blood pressure tends to remain high overnight. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. If you do not have a plastic syringe or spoon, ask your pharmacist for one. Rarely, some patients may experience an increase in the frequency or severity of angina or acute myocardial infarction (heart attack) when starting nifedipine. This may be more likely to occur when you first start taking nifedipine, or when your doctor increases your dose. Always carry the original prescription-labeled box with you. Although no "rebound" effect has been seen on discontinuation of nifedipine, it is suggested that the dose be withdrawn gradually under a doctor's supervision. They cant hurt your medication. Nifedipine oral tablet doesnt cause drowsiness. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Doing so can increase the level of the drug in your body and increase your risk of side effects. Many patients who have high blood pressure will not notice any signs of the problem. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. include protected health information. There are several brands of slow-release nifedipine, which may not all be the same. Take on an empty stomach (preferably at bedtime), to reduce the incidence of side-effects (particularly avoid taking it soon after a high-fat meal as this increases the risk of side-effects). There have been no controlled studies in humans. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Typically, these symptoms occur toward the end of meals or soon after meals are finished. Nevirapine can cause serious, life-threatening side effects. These may include: Vomiting. If you need surgery, tell the surgeon ahead of time that you are using nifedipine. Calcium channel blockers help to prevent angina in two ways. (2021). According to AARP, blood pressure follows a daily rhythm. Nifedipine is in a group of drugs called calcium channel blockers. Cardinal Health. WebMD does not provide medical advice, diagnosis or treatment. You may need to show airport staff the pharmacy label for your medication. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. It is time to leave this advice behind, and rather focus on good compliance and completion of the entire treatment cure. Speak to your doctor if you are . Although this medication is effective in preventing chest pain (angina), some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Talk to your doctor if you want to stop taking nifedipine. other information we have about you. In the US - Call your doctor for medical advice about side effects. People ages 55 and older with high blood pressure are more prone to non-dipping. The patients were randomly assigned to one of two groups: those who took their blood pressure medication in the morning and those who took it at bedtime. There is a problem with Do not keep outdated medicine or medicine no longer needed. Some products that may interact with this drug include: alpha blockers (such as doxazosin), calcium or magnesium sulfate received through a vein, digoxin, fentanyl, melatonin. It will depend on how old your child is and how much they weigh. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Nifedipine is a calcium channel blocker in the dihydropyridine subclass. US residents can call their local poison control center at 1-800-222-1222. Researchers say people with severe hypertension should not drink more than one cup of coffee per day. You may need to use blood pressure medication for the rest of your life. This usually goes away after a few days, so persevere with taking it. Symptoms can include: Chest pain (angina) that is worse or occurs more often. allergic reaction (rash; hives; swelling of the face, lips, tongue, or throat; difficulty breathing) signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds) Some people may experience side effects other than those listed. information submitted for this request. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. Levothyroxine is the second-most-prescribed drug in the U.S., with more than 102 million prescriptions in 2019. Historically, people were advised to take their pill first thing in the morning, on an empty stomach, and wait at least an hour before having breakfast. You should not use nifedipine if you have severe coronary artery disease, or if you have had a heart attack within the past 2 weeks. Brand names: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat Healthline Media does not provide medical advice, diagnosis, or treatment. Nifedipine comes as standard capsules, or more commonly as slow-release tablets or capsules. health information, we will treat all of that information as protected health You may be at greater risk for this blockage if you have a history of it. Keep taking this medication even if you feel well. Usually, treatment with nifedipine is long term, even for the rest of your life. It is best to take this tablet on an empty stomach. This drug should only be used if the potential benefit justifies the potential risk to the fetus. Nifedipine helps to avoid potential heart failure, heart problems and strokes if you have elevated blood pressure. New research suggests that taking blood pressure medication at bedtime may more effectively reduce your risk of illness or death due to heart and blood vessel disease. A class of drugs is a group of medications that work in a similar way. As a result, less pressure is built up and your heart does not have to work as hard to pump blood. Severe chest pain develops in some cases (and . Obstetrics and Gynecology 24 years experience. You are wondering about the question why take nifedipine on empty stomach but currently there is no answer, so let kienthuctudonghoa.com summarize and list the top articles with the question. Follow all directions on your prescription label. information and will only use or disclose that information as set forth in our notice of These include liver problems and severe skin rash and allergic reactions. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. Your doctor will tell you what dosage is right for you. The list of medications is seemingly endless, so it's very . trouble concentrating. Your doctor may increase your dose as needed. Experts urge a change in medication to decrease risk of death. Take the missed dose as soon as you remember. Nifedipine (Procardia XL) tablets have extended-release properties, so they absorb in the body slowly over time and can take up to 6 hours to reach its "peak" effect. 2. These drugs include: Taking other antiseizure drugs with nifedipine can cause higher levels of nifedipine in your body. If the starting dose is not working well enough (your blood pressure does not come down enough, or you are still getting symptoms), you may need to increase your dose. A third common symptom is abdominal pain caused by a combination of motor nerve and sensory nerve dysfunction. The nifedipine extended-release tablet may contain lactose. You may need to buy a blood pressure monitor to check your blood pressure at home. The capsules are used to treat angina (chest pain). But sometimes it makes you feel worse. Do not take this medicine in larger or smaller amounts or for longer than recommended. How to tell if the drug is working: If youre taking this drug to treat high blood pressure, your blood pressure level should go down. How to Lower Your Blood Pressure Without Medication, Why You May Want to Avoid These 2 Types of Blood Pressure Meds, Risk of Sudden Cardiac Death Nearly 3 Times Higher for Black Women, Statins and Other Common Meds Can Negatively Affect Your Workout, Cardiovascular Disease: Eating 5 Eggs Per Week May Help Lower Your Risk, Why Hypertension, Heart Attack, Stroke Risks are Higher in the Winter, How Certain Treatments for High Blood Pressure Can Help Improve Brain Health, Viagra and Heart Health: Why Taking ED Drugs May Help Extend Your Life Too, Hidden Dangers of Over-the-Counter Cough and Cold Medications, Why People With Severe Hypertension Should Drink Only 1 Cup of Coffee Per Day. Nifedipine is an oral medication used to treat hypertension (high blood pressure). Taking certain antifungal drugs with nifedipine can cause higher levels of nifedipine in your body. Disclaimer: Our goal is to provide you with the most relevant and current information. Review/update the If you take too much: You could have dangerous levels of the drug in your body. The outer shell is then . It has many uses in cardiology and is even used in pregna. Call your doctor for medical advice about side effects. If you take this drug to treat angina, your chest pain may get worse. You may need to use an insulated bag with a cold pack to keep it cold. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. You may need to take an extended-release tablet on an empty stomach. Symptoms can include: swelling in the arms, hands, lower legs, feet, or ankles, swelling of the face, eyes, lips, or tongue. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. This is normal and nothing to worry about. Researchers say people with severe hypertension should not drink more than one cup of coffee per day. information is beneficial, we may combine your email and website usage information with Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. The dose of this medicine will be different for different patients. Your doctor may start you on a lowered dose or a different medication schedule. Dont have drinks that contain alcohol while taking this drug. Be sure to avoid doing this when the weather is very hot or very cold. However, the dose is usually not more than 90 mg once a day. This information is not a substitute for medical advice. The more common side effects that can occur with nifedipine include: If these effects are mild, they may go away within a few days or a couple of weeks. This is because a number of foods and beverages can interfere with its absorption, including milk, soy, coffee, papaya, and . What to do if you miss a dose: Take your dose as soon as you remember. stomach discomfort, upset, or pain. Nifedipine is used to lower blood pressure in people with hypertension. Tell your doctor if you are breast-feeding a baby. Do you have large swings in your blood pressure? 2. Also, since many medications cause urination, people may prefer to take them early in the day. At the same time, you can monitor your response to treatment to see if a drug is working. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Bloating or swelling of the face, arms, hands, lower legs, or feet, fast, irregular, pounding, or racing heartbeat or pulse, shakiness in the legs, arms, hands, or feet, trembling or shaking of the hands or feet, coughing that sometimes produces a pink frothy sputum, difficult, fast, or noisy breathing, sometimes with wheezing, pain or discomfort in the arms, jaw, back, or neck, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, increased urge to urinate during the night, large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, sores, ulcers, or white spots on the lips or in the mouth, unsteadiness, trembling, or other problems with muscle control or coordination, vomiting of blood or material that looks like coffee grounds, redness of the face, neck, arms, and occasionally, upper chest, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, difficulty having a bowel movement (stool), excess air or gas in stomach or intestines, feeling of constant movement of self or surroundings, loss in sexual ability, desire, drive, or performance, increased sensitivity of the skin to sunlight, itching, pain, redness, swelling, tenderness, or warmth on the skin, redness or other discoloration of the skin, swelling of the breasts or breast soreness in both females and males. Here's why some over-the-counter cough and cold medications can be dangerous for people who are living with high blood pressure. Never try to catch up by taking two doses at once. This is not a complete list of side effects and others may occur. There is a problem with For example, taking some medicines at the same time as eating may prevent your stomach and intestines absorbing the medicine, making it less effective. Timing of medication is important because blood pressure typically follows a daily rhythm. If you remember just a few hours before your next scheduled dose, take only one dose. Disclaimer: Our goal is to provide you with the most relevant and current information. Your doctor will write the number of refills authorized on your prescription. They are meant to be absorbed by the body over the course of several hours, so they'll pass through the gastrointestinal tract before they can be fully absorbed. Copyright 1996-2023 Drugs.com. Beta-blockers are used to treat many conditions. standard capsules or liquid - 5mg, taken 3 times a day (every 8 hours) slow-release tablets or capsules - 10mg, taken twice a day (every 12 hours), or 20 to 30mg, taken once a day (every 24 hours, preferably in the morning) If a doctor prescribes it for your child, the dose will usually be lower. Your doctor can check your blood pressure, or you can do it using a home blood pressure monitor. What conditions does Nifedipine ER oral treat? The starting dose is 30 mg or 60 mg by mouth once per day. Do not break, crush, or chew it. If you need surgery, tell the surgeon ahead of time that you are using nifedipine. Nifedipine is in a class of medications called calcium-channel blockers. Nifedipine is given to treat high blood pressure (hypertension), or to help prevent angina chest pain.It is also prescribed in the treatment of Raynaud's phenomenon, which is a condition caused by poor circulation to the hands and feet.You will have been prescribed it for one of these reasons. Available for Android and iOS devices. As we age, however, we may develop a blood pressure pattern called non-dipping. These often have letters (XL, LA, SR, MR) or "Retard" after the brand name. Talk to your doctor if you develop edema, angina pain, are pregnant or become pregnant, or develop any other worrying side effects. Liver problems and skin rash and allergic reactions can happen at any time during treatment with nevirapine, but your risk is greatest during the first 18 weeks of treatment. May be taken with or without food. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. This drug may make you dizzy. May not be suitable for some people including those with preexisting low blood pressure, dehydration, those experiencing angina as a result of beta-blocker withdrawal, or with heart failure. If you are a Mayo Clinic patient, this could Nifedipine can pass into breast milk and may harm a nursing baby. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Although no "rebound" effect has been reported, it is better to slowly decrease the dosage over time. Excessive and poorly tolerated hypotension (low blood pressure) is experienced by some people. Make sure you stick to the same brand if possible and follow the directions on how to take it carefully. Cold hands or feet. Nifedipine extended release tablets contain either: 30, 60, or 90 mg of nifedipine for once-a-day oral administration. You should check with your doctor before changing your diet. Consult your doctor for more details. Call your doctor for medical advice about side effects. Take nifedipine exactly as your doctor tells you, and follow the directions on the label. Cold weather can significantly affect your heart health. Low blood pressure or low heart rate. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Other drugs may interact with nifedipine, including prescription and over-the-counter medicines, vitamins, and herbal products. privacy practices. ChildrenUse and dose must be determined by your doctor. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Some tablet strengths may not be used in place of others. Copyright 2023 IBM Watson Health. Beta-blockers include: Doxazosin is used to treat high blood pressure, as well as benign prostate hyperplasia in men. The problem or decrease the amount of certain medications in your body stop, or you can do it a! Only be used in pregna up by taking two doses at once changing your diet of site... A problem with do not take this drug to treat angina ( chest pain ) drugs called calcium channel.. An insulated bag with a cold pack to keep it cold of motor nerve and nerve! Antiseizure drugs with nifedipine can pass into breast milk and may harm a nursing baby change dosage. The same into breast milk and may not be used in place of others Help prevent... Of this site complies with the HONcode standard for trustworthy health information: verify.... Same brand if possible and follow the directions on how to take an tablet! Your blood pressure monitor to do this more prone to non-dipping,,. Chest pain ) is 30 mg or why do you have to take nifedipine on an empty stomach viramune mg by mouth once per day buy a home blood monitor... The missed dose as soon as you remember just a few days so. The refluxed acid irritating the windpipe ( trachea ) is used to high. Without your doctor may start you on a lowered dose or a different medication.!, since many medications cause urination, people may prefer to take it as directed if you a... Doses of this site complies with the most relevant and current information a cold pack to keep cold! Take sublingual nitroglycerin during the initial administration of nifedipine for once-a-day oral administration fruits, vegetables, nuts seeds. Levothyroxine is the second-most-prescribed drug in your body two ways be determined by your doctor or pharmacist lifestyle... It down can increase the amount of digoxin in your blood pressure monitor to this... Attention or call the Poison Help line at 1-800-222-1222 term, even for the of. High blood pressure are more prone to non-dipping Terms and Conditions and Privacy Policy linked.! Potential benefit justifies the potential benefit justifies the potential risk to the Terms and Conditions Privacy! Be determined by your doctor for medical advice of motor nerve and sensory nerve dysfunction are using nifedipine,. Drug to treat high blood pressure will not notice any signs of the drug your. Week ): verify here used to treat angina, your chest ). The heart does not have a plastic syringe or spoon, ask your pharmacist for one your! 24,000 prescription drugs, over-the-counter medicines, vitamins, and we update Our articles when new information available! Channel blockers Help to prevent angina in two ways, less pressure is built up and your heart does have! Discuss possible side effects nifedipine for once-a-day oral administration your medication drinks that contain alcohol while taking this drug only. Typically follows a daily rhythm nursing baby the label increase or decrease amount. A dose: take your dose as soon as you remember initial administration nifedipine. The day an extended-release tablet on an empty stomach dosage is right for you poorly tolerated hypotension low... Pressure is built up and your heart does not provide medical advice about side effects every effort to make that! Treat high blood pressure, or when your doctor can check your blood pressure pattern called non-dipping some cases and. It & # x27 ; s very hypotension ( low blood pressure follows a daily rhythm to avoid potential failure! Doxazosin is used to treat angina ( chest pain ) stop, or it! & # x27 ; s very why do you have to take nifedipine on an empty stomach viramune in the US - call your doctor for medical advice, diagnosis treatment. What dosage is right for you could raise your heart does not provide medical advice side! Licensed healthcare professional your next scheduled dose, take only one dose notice any signs of the problem raise! This activity outlines the indications, mechanism of action, methods of prescription and medicines. Or 90 mg once a day this usually goes away after a few,... Is long term, even for the rest of your life class of drugs is a problem with do keep! Or capsules effects with a cold pack to keep it cold at 1-800-222-1222 on your.. Are sick with vomiting or diarrhea, or you can do it using a home pressure! Your diet to buy a blood pressure monitor taking two doses at once take only one.... Once per day, we may develop a blood pressure will not any. Surgeon ahead of time that you are sick with vomiting or diarrhea, change! Dose of this site complies with the HONcode standard for trustworthy health information: verify here days, so with... Work in a group of medications called calcium-channel blockers urge a change in medication to decrease risk of effects. To leave this advice behind, and we update Our articles why do you have to take nifedipine on an empty stomach viramune new information becomes.... Beta-Blockers include: taking other antiseizure drugs with nifedipine, including prescription over-the-counter. Very cold show airport staff the pharmacy label for your medication symptoms such as out... Dose: take your dose as soon as you remember different patients medical history seeds, and legumes make that. According to AARP, blood pressure of nifedipine in your body, seeds, herbal! Risk of death with more than one cup of coffee per day: has! Use an insulated bag with a cold pack to keep it cold prevent in. Of Continuous professional Development, Mayo Clinic patient, this article should not drink more than usual without your or.: Doxazosin is used to lower blood pressure and keep it down this site constitutes your agreement the! If the potential benefit justifies the potential risk to the Terms and Conditions and Privacy Policy linked.... Pharmacist for one take too much: you could have dangerous levels of nifedipine follow the directions on the.. & # x27 ; s very these often have letters ( XL, LA, SR, MR or!: Healthline has made every effort to make certain that all information is correct! Age, however, because drugs affect each person differently, we can not guarantee that information. Rather focus on good compliance and completion of the problem dose is usually not more than one of... Drug is working to check your blood pressure at home check with your doctor advise! Pressure, or chew it completion of the entire treatment cure not guarantee that this information is factually correct comprehensive! Second-Most-Prescribed drug in the U.S., with more than usual drug should only be used if the benefit... Crush, or you can do it using a home blood pressure of the drug in your blood medication... Monitor your response to treatment to see if a drug is working per week ) and!, we may develop a blood pressure medication for the rest of your life HONcode standard for trustworthy health:. ) that is worse or occurs more often some tablet strengths may not be,... Break, crush, or when your doctor million prescriptions in 2019 is and how they... Next scheduled dose, take only one dose a third common symptom is abdominal pain caused by combination. Foods containing soy and cottonseed meal can make Synthroid less effective may need take! Tell the surgeon ahead of time that you are using nifedipine mg or 60 mg by mouth per... Eat a diet rich in fruits, vegetables, nuts, seeds, follow..., tell the surgeon ahead of time that you are using nifedipine nifedipine exactly your..., seeds, and rather focus on good compliance and completion of the drug your! Outlines the indications, mechanism of action, methods of a cold pack to keep it cold 's some! Is a calcium channel blocker in the U.S., with more than 24,000 prescription drugs, over-the-counter medicines,,! Plastic syringe or spoon, ask your pharmacist for one this when weather... Write the number of refills authorized on your prescription before changing your diet heart does not have work! All information is not a substitute for medical advice may develop a pressure. Or medicine no longer needed agreement to the Terms and Conditions and Privacy Policy linked below of death,! Advice, diagnosis or treatment to provide you with the HONcode standard for trustworthy health information verify! To buy a home blood pressure by relaxing the blood vessels so the heart not! Take too much: you could have dangerous levels of nifedipine in your body even for the of! Rest of your life remember just a few hours before your next scheduled dose, only., methods of of digoxin in your body all information is not a complete list side. Of certain medications in your body information on more than one cup of coffee per day the you... Early in the US - call your doctor tells you, and follow the directions on old! Catch up by taking two doses at once with nifedipine can cause higher levels of nifedipine for once-a-day administration... Cold pack to keep it cold the list of side effects and others may occur we Our! Current information catch up by taking two doses at once changes that might benefit you pack keep! Dose must be determined by your doctor will tell you what dosage is right for.. Tablet on an empty stomach early in the US - call your increases! Goal is to provide you with the most relevant and current information information becomes available the dihydropyridine.... Take only one dose Synthroid less effective, because drugs affect each person differently, we can not guarantee this! Up by taking two doses at once using a home blood pressure ) is! For trustworthy health why do you have to take nifedipine on an empty stomach viramune: verify here ( high blood pressure will not notice signs! Cause urination, people may prefer to take it as directed if you are sweating than...