S Afr Med J 63 [Ref], Common (1% to 10%): Diffuse skin rash, erythema, erythroderma, exfoliative dermatitis, Lyell syndrome, pruritus, rash, sweating, urticaria, Rare (0.01% to 0.1%): Eosinophilia systemic symptoms, toxic epidermal necrolysis, Frequency not reported: Acne, exfoliative dermatitis, exfoliative skin eruptions, maculopapular skin eruptions, morbilliform skin eruptions, purpuric skin eruptions, pemphigus, rash, Stevens-Johnson syndrome, Rare (0.01% to 0.1%): Acne, photosensitivity, Frequency not reported: Erythema, pruritus, rash, urticaria, Frequency not reported: Allergic dermatitis, erythema multiforme, face edema, itching with/without rash, pemphigoid, pruritus, rash pruritic, skin reaction, Stevens-Johnson syndrome, sweat discoloration, toxic epidermal necrolysis, urticaria[Ref], Common (1% to 10%): Diabetic coma, diffuse paresthesia of the legs, headache, vertigo, vertigo with loss of equilibrium, Common (1% to 10%): Peripheral neuropathy, Frequency not reported: Convulsions, loss of tendon reflexes, memory impairment, paresthesia, polyneuritis, toxic encephalopathy, vertigo, Frequency not reported: Ataxia, cerebral hemorrhage/fatal cerebral hemorrhage, drowsiness, generalized numbness, inability to concentrate[Ref]. (2001): 733-5, Danan G, Pessayre D, Larrey D, Benhamou JP "Pyrazinamide fulminant hepatitis: an old hepatotoxin strikes again." Gout is found more commonly in men, but women and teens are developing it due to the high amounts of animal products consumed in the diet. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Major Potential Hazard, High plausibility. We comply with the HONcode standard for trustworthy health information -, Drug class: antituberculosis combinations, fast, irregular, pounding, or racing heartbeat or pulse, ringing or buzzing or other unexplained noise in the ears, blistering, peeling, or loosening of the skin, blurred vision or loss of vision, with or without, feeling that others are watching you or controlling your behavior, feeling that others can hear your thoughts, feeling, seeing, or hearing things that are not there, greatly decreased frequency of urination or amount of urine, persistent bleeding or oozing from puncture sites, mouth, or nose, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, ankles, fingers, hands, or lower legs, unusual drowsiness, dullness, or feeling of sluggishness, inability to move the arms, legs, or facial muscles, pains in the stomach, side, or abdomen, possibly radiating to the back, red skin lesions, often with a purple center, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, feeling of fullness in the upper abdomen or stomach, reddish-orange to reddish-brown color of the urine, stool, saliva, sputum, sweat, and tears, seeing, hearing, or feeling things that are not there, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, excess air or gas in the stomach or bowels, pain or discomfort in the chest, upper stomach, or throat, swelling of the breasts or breast soreness in both females and males. Rifater (isoniazid / pyrazinamide / rifampin)." Moderate Potential Hazard, Moderate plausibility. If you change your diet and reduce or eliminate the amount of animal protein you consume, your risk for developing new stones is greatly reduced. Select one or more newsletters to continue. 3. Therapy with pyrazinamide should be administered cautiously and under strict medical supervision in patients with liver disease or a history of alcoholism. Dosage reductions are recommended in these patients if the drug is used. The use of pyrazinamide is contraindicated in patients with acute gout. Pyrazinamide may cause hepatocellular injury, particularly in patients with underlying liver disease and during coadministration with other hepatotoxic agents including other antituberculous drugs such as isoniazid and rifampin. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The most dangerous side effect of pyrazinamide is hepatotoxicity, which is dose-related. DICP 24 The body goes into a particular state known as huperuricemia as a result of being exposed to an over-abundance of uric acid. 123.11Each Pyrazinamide tablet for oral administration contains 500 mg of Pyrazinamide and the following inactive ingredients: Corn Starch, Magnesium Stearate, Pregelatinized Starch a… [Ref], Frequency not reported: Agranulocytosis, anemia, aplastic anemia, eosinophilia, hemolytic anemia, lymphadenopathy, sideroblastic anemia, thrombocytopenia, Rare (0.01% to 0.1%): Adverse effects on blood clotting mechanisms, erythrocyte vacuolation, increased concentration of erythrocytes, Frequency not reported: Sideroblastic anemia, thrombocytopenia with/without purpura, Common (1% to 10%): Thrombocytopenia with/without purpura, Rare (0.01% to 0.1%): Agranulocytosis, disseminated intravascular coagulation, hemolysis, Frequency not reported: Decreased hemoglobin, eosinophilia, hemolytic anemia[Ref], Common (1% to 10%): Generalized hypersensitivity, Frequency not reported: Anaphylactic reactions, hypersensitivity reactions, Frequency not reported: Hypersensitivity reactions, Frequency not reported: Anaphylactic reaction[Ref], Acute renal failure, acute tubular necrosis, hematuria, hemoglobinuria, hemolysis, interstitial nephritis, and renal insufficiency are considered hypersensitivity reactions to rifampin, and usually occurred during intermittent treatment or upon resumption of treatment following intentional/accidental interruption of a daily regimen; these reactions were reversible when this drug was discontinued and appropriate therapy was given. The stones may range in size from grains of sand to large chunks that resemble rocks on the ground.

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